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Solutions of poly(N-isopropylacrylamide) (polyNIPAAm) become turbid at their lower critical solution temperature (LCST) of 33°C. In this study we have conjugated a phospholipid, 1-acyl-2-{ 12-[(7-nitro- 2-1,3-benzoxadiazol-4-yl)amino]dodecanol}-phosphatidylethanolamine, to polyNIPAAm. Conjugation increases the LCST of polyNIPAAm by ~ 2°C and broadens the temperature range over which turbidity changes. Conjugation of phospholipids to polymers in general and to thermally reversible polymers in particular may allow some novel applications that relate to their potential for insertion into liposomes, micelles or cell membranes and hydrophobic interfaces.

Посилання на статтю:

Conjugation of phosphatidylethanolamine to poly(N-isopropylacrylamide) for potential use in liposomal drug delivery systems / Xue Shen Wu, Allan S. Hoffman* and Paul Yager // Polymer. – 1992. – Vol 33. – P. 4659-4662.

Conjugation of phosphatidylethanolamine to poly(N-isopropylacrylamide) for potential use in liposomal drug delivery systems - Завантажити.