Poly(L-glutamic acid) (PLG) membranes were prepared by crosslinking poly[~-(2-chloroethyl) L-glutamate] with diethylenetriamine and subsequently hydrolysing the side-chain esters. Selective amino acid transport across the membrane was examined using L-phenylglycine, L-phenylalanine and L-tryptophan. Transport selectivity increased with increasing pH of the solute solution, i.e. from 2.0 to 5.7. When pH was raised to 8.0 or when CaCI2 was added, transport selectivity was lost. Conformational changes of PLG and electrostatic interactions between the solute and the membrane are suggested to cause the observed permselectivity behaviour.
Посилання на статтю:
Selective transport of amino acids across a crosslinked poly(L-glutamic acid) membrane / Masaki Sato*, Akihiro Ichige, Tomoko Emura, Megumi Yoshimoto,Takayuki Nakahira~, Susumu Iwabuchi and Kuniharu Kojima // Polymer. – 1993. – Vol 34. – P. 1237-1239.